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PROSPECT (Providing Regional Observations to Study Predictors of Events in the Coronary Tree) was the first prospective, international, multicenter, natural history study using 3-vessel multimodality intracoronary imaging to quantify the clinical event rate due to atherosclerotic progression and to identify those lesions which place patients at risk for unexpected adverse cardiovascular events. This landmark study of 700 Acute Coronary Syndrome (ACS) patients was co-funded by Volcano and utilized Volcano's proprietary VH® IVUS technology to classify lesions by plaque type. Three-year clinical event data was presented by Dr. Gregg Stone of Columbia University Medical Center on September 24, 2009 at the Transcatheter Cardiovascular Therapeutics (TCT) conference in San Francisco, CA.

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VH IVUS Lesion Assessment

Comments from Early Collaborators

"VH IVUS is the first IVUS system capable of providing information in the cardiac catheterization laboratory about the plaque composition" said Martin B. Leon, MD Chairman of the Cardiovascular Research Foundation® and the Associate Director of the Center for Interventional Vascular Therapy (CIVT) at Columbia University Medical Center, New York City. Dr. Leon continued, "This impressive technology will assist us in interpreting our ultrasound results and is expected to provide important new information to guide the management of our patients. We are aggressively studying this new technology and assessing its optimal role in the cath lab."

Professor Patrick W. Serruys, Thoraxcentre, Erasmus Medical Center, Rotterdam, The Netherlands commented: "The use of IVUS today is generally focused on providing geometric measurements of the vessel and lumen. Due to IVUS' inability to display plaques other than as grayscale renderings, interventionalists have had difficulty drawing conclusions about the plaque type or disease type seen in individual patients. Plaque imaging using VH IVUS will provide key information and may shift the paradigm of how we diagnose and manage patients with cardiovascular disease."