PROSPECT (Providing Regional Observations to Study Predictors of Events in the Coronary Tree) was the first prospective, international, multicenter, natural history study using 3-vessel multimodality intracoronary imaging to quantify the clinical event rate due to atherosclerotic progression and to identify those lesions which place patients at risk for unexpected adverse cardiovascular events. This landmark study of 700 Acute Coronary Syndrome (ACS) patients was co-funded by Volcano and utilized Volcano's proprietary VH® IVUS technology to classify lesions by plaque type. Three-year clinical event data was presented by Dr. Gregg Stone of Columbia University Medical Center on September 24, 2009 at the Transcatheter Cardiovascular Therapeutics (TCT) conference in San Francisco, CA.

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VH IVUS Lesion Assessment

VH® IVUS Publications

Technical Papers



Topic Year Publication Link
Volcano - Validation 2007 Nair, A., Margolis, M. P., Kuban, B., Vince, D. G. "Automated coronary plaque characterisation with intravascular ultrasound backscatter:ex vivo validation". EuroIntervention 3 (2007): 113-120. Abstract/ Link to PDF
Advanced Spectral Analysis 2004 Nair, A., Calvetti, D., et.al. "Regularized Autoregressive Analysis of Intravascular Ultrasound Backscatter: Improvement in Spatial Accuracy of Tissue Maps". IEEE Transactions on Ultrasonic's Ferroelectrics and Frequency Control 51.4 (2004): 420-431. Abstract
Validation, autoborders 2003 Klingensmith, J. D., Tuzcu, E. M., Nissen, S., Vince, D. G. "Validation of an automated system for luminal and medial-adventitial borders detection in three-dimensional intravascular ultrasound". International Journal of Cardiovascular Imaging 19.2 (2003): 93-104. Abstract
Validation 2002 Nair, A., Kuban, B., Tuzku, E. M., Schonhagen, P., Nissen, S., Vince, G.. "Coronary Plaque Classification with Intravascular Unltrasound Radiofrequency Data Analysis.". Circulation 106 (2002): 2200-2206. PDF
Advanced Spectral Analysis 2002 Klingensmith, J. D., Vince, D. G.. "B-Spline Methods for Interactive Segmentation and Modeling of Lumen and Vessel Surfaces in Three-Dimensional Intravascular Ultrasound". Computerized Medical Imaging and Graphics 26.6 (2002): 429-438. Abstract
UltraCross Technical Analysis 2001 Nair, A., Kuban, B., Obychowski, N., Vince, G. "Assessing Spectral Algorithms to Predict Atherosclerotic Plaque Composition with Normalized and Raw IVUS Data". Ultrasound in Medicine and Biology 27.10 (2001): 1319-1331. Abstract
Validation, autoborders 2000 Klingensmith, J. D., Shekhar, R., et. al. "Evaluation of Three-Dimensional Segmentation Algorithms for the Identification of Luminal and Medial-Adventitial Borders in Intravascular Ultrasound Images". IEEE Transactions on Medical Imaging 19.10 (2000): 996-1011. Abstract

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